Kamata T, Sakamaki F, Fujita H, Urano T, Mori M, Yamaguchi K, Kanazawa M, Kai M, Izumi T, Naka W
Department of Medicine, School of Medicine, Keio University, Tokyo.
Intern Med. 1994 Apr;33(4):252-5. doi: 10.2169/internalmedicine.33.252.
A 55-year-old man developed multiple erythematous skin lesions after surgery for acoustic neurinoma. Necrosis and detachment of the epidermis developed and a diagnosis of toxic epidermal necrolysis (TEN) was made. Progressive dyspnea was evident two days after the onset of the skin lesions. Chest X-ray revealed diffuse interstitial shadows in both lung fields. On bronchoscopic examination, erosion, vesicle formation, necrosis and desquamation of the epidermis were seen in the tracheobronchial mucosa. Therapy, including prednisolone, improved the skin lesions as well as the chest X-ray and bronchoscopic findings. Tracheobronchial and pulmonary lesions were followed before, during and after treatment of TEN.
一名55岁男性在听神经瘤手术后出现多处皮肤红斑性病变。表皮发生坏死和脱落，诊断为中毒性表皮坏死松解症（TEN）。皮肤病变出现两天后，进行性呼吸困难明显。胸部X线显示双肺野弥漫性间质阴影。支气管镜检查发现气管支气管黏膜有糜烂、水疱形成、坏死和表皮脱落。包括泼尼松龙在内的治疗改善了皮肤病变以及胸部X线和支气管镜检查结果。在TEN治疗前、治疗期间和治疗后对气管支气管和肺部病变进行了跟踪观察。
