McCully J D, Tsukube T, Ataka K, Krukenkamp I B, Feinberg H, Levitsky S
Division of Cardiothoracic Surgery, New England Deaconess Hospital, Boston, Massachusetts.
J Card Surg. 1994 May;9(3 Suppl):449-52. doi: 10.1111/jocs.1994.9.3s.449.
Cytosolic calcium in the myocardium is rapidly accumulated during ischemia and has been correlated with the attenuation of functional recovery in the myocardium. The aged myocardium is more sensitive to ischemia and accumulates significantly more cytosolic calcium than either the newborn or the mature myocardium. Modification of the age-related propensity to increased cytosolic calcium accumulation may be achieved through the use of magnesium or potassium/magnesium cardioplegia. Improved postischemic ventricular function obtained with magnesium or potassium/magnesium cardioplegia may have important implications in the reduction of myocardial morbidity and mortality.
心肌中的胞质钙在缺血期间会迅速积聚，并且与心肌功能恢复的减弱相关。老年心肌对缺血更为敏感，其胞质钙的积聚量明显多于新生心肌或成熟心肌。通过使用镁或钾/镁停搏液，可以改变与年龄相关的胞质钙积聚增加的倾向。使用镁或钾/镁停搏液获得的缺血后心室功能改善，可能对降低心肌发病率和死亡率具有重要意义。
