巨噬细胞激活对荷肉瘤-180小鼠中空脂质体包裹的3H-甲氨蝶呤血浆处置的影响。
Effect of macrophage activation on plasma disposition of niosomal 3H-methotrexate in sarcoma-180 bearing mice.
作者信息
Chandraprakash K S, Udupa N, Umadevi P, Pillai G K
机构信息
College of Pharmaceutical Sciences, Kasturba Medical College, Manipal, India.
出版信息
J Drug Target. 1993;1(2):143-5. doi: 10.3109/10611869308996070.
Methotrexate niosomes were formed by reverse phase evaporation technique using sorbitan monostearate (Span 60) surfactant. The pharmacokinetic parameters of methotrexate (MTX) after macrophage activation via muramyl dipeptide gelatin conjugate were studied and the results compared with those obtained after free MTX and MTX niosomes without macrophage activation. In mice MTX concentrations and tumour regression were higher after macrophage activation.
采用反向蒸发技术，使用单硬脂酸山梨醇酯（司盘60）表面活性剂制备甲氨蝶呤脂质体。研究了经胞壁酰二肽明胶缀合物激活巨噬细胞后甲氨蝶呤（MTX）的药代动力学参数，并将结果与游离MTX和未激活巨噬细胞的MTX脂质体的结果进行比较。在小鼠中，激活巨噬细胞后MTX浓度和肿瘤消退情况更高。
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