蝾螈视网膜中的多唾液酸表达可被甲状腺素诱导。
Polysialic acid expression in the salamander retina is inducible by thyroxine.
作者信息
Becker C G, Becker T, Schmidt A, Roth G
机构信息
Brain Research Institute, University of Bremen, Germany.
出版信息
Brain Res Dev Brain Res. 1994 May 13;79(1):140-6. doi: 10.1016/0165-3806(94)90059-0.
Polysialylation of the neural cell adhesion molecule (NCAM) in the retina of Pleurodeles waltl is up-regulated during metamorphosis. Incubation of larvae in thyroxine permanently induced polysialic acid expression in the retina in a concentration-dependent but age-independent manner within 3 days of incubation (3 x 10(-7) M). Retinoic acid had no effect. This suggests direct hormonal regulation of a post-translational modification of NCAM in the amphibian retina.
在美西螈变态期间，其视网膜中神经细胞黏附分子（NCAM）的多唾液酸化上调。将幼虫置于甲状腺素中孵育，在孵育3天内（3×10⁻⁷M），能以浓度依赖但与年龄无关的方式永久性诱导视网膜中多唾液酸的表达。视黄酸无此作用。这表明两栖动物视网膜中NCAM的翻译后修饰存在直接的激素调节。
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