Watanabe T, Sobu K, Takase Y, Kawabata T, Kanno M, Yoshida T
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
Jpn J Antibiot. 1994 Jun;47(6):701-9.
Combination effects were studied with arbekacin (ABK) and beta-lactam antibiotics including imipenem/cilastatin (IPM/CS), flomoxef (FMOX), and cefotiam (CTM) for bactericidal activities, post-antibiotic effects (PAE's) and bactericidal activities of beta-lactam antibiotics after removal of ABK using methicillin-resistant Staphylococcus aureus (MRSA) strain 1936. The following results were obtained. 1. When ABK was administered in combination with IPM/CS, FMOX or CTM against MRSA strain 1936, low FIC index was not obtained. 2. Higher bactericidal activity was observed when ABK was given before beta-lactam than when beta-lactam was given before ABK. 3. Combination of ABK and each of beta-lactam antibiotic led a longer PAE than ABK alone. 4. When each beta-lactam antibiotic was administered after a treatment and removal of ABK, greater bactericidal activity and growth inhibition were observed than when administered each beta-lactam alone. These findings basically demonstrated that ABK was effectively bactericidal against MRSA when administered in combination with beta-lactam antibiotic such as IPM/CS, FMOX or CTM, even when the FIC index did not indicate a favorable effect.
使用耐甲氧西林金黄色葡萄球菌（MRSA）1936菌株，研究了阿贝卡星（ABK）与包括亚胺培南/西司他丁（IPM/CS）、氟氧头孢（FMOX）和头孢替安（CTM）在内的β-内酰胺类抗生素联合使用时的杀菌活性、抗生素后效应（PAE）以及去除ABK后β-内酰胺类抗生素的杀菌活性。得到以下结果。1. 当ABK与IPM/CS、FMOX或CTM联合用于MRSA菌株1936时，未获得低FIC指数。2. 与先给予β-内酰胺类抗生素再给予ABK相比，先给予ABK再给予β-内酰胺类抗生素时观察到更高的杀菌活性。3. ABK与每种β-内酰胺类抗生素联合使用导致的PAE比单独使用ABK更长。4. 当在给予并去除ABK后给予每种β-内酰胺类抗生素时，观察到的杀菌活性和生长抑制作用比单独给予每种β-内酰胺类抗生素时更强。这些发现基本证明，即使FIC指数未显示出良好效果，但ABK与IPM/CS、FMOX或CTM等β-内酰胺类抗生素联合使用时，对MRSA具有有效的杀菌作用。
