缺乏转录因子GATA-2的小鼠早期造血缺陷。

An early haematopoietic defect in mice lacking the transcription factor GATA-2.

作者信息

Tsai F Y, Keller G, Kuo F C, Weiss M, Chen J, Rosenblatt M, Alt F W, Orkin S H

机构信息

Division of Hematology-Oncology, Children's Hospital, Boston, Massachusetts.

出版信息

Nature. 1994 Sep 15;371(6494):221-6. doi: 10.1038/371221a0.

DOI:10.1038/371221a0

PMID:8078582

Abstract

Blood cell development relies on the expansion and maintenance of haematopoietic stem and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we demonstrate that the transcription factor GATA-2 plays a critical role in haematopoiesis, particularly of an adult type. We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells.

摘要

血细胞发育依赖于胚胎中造血干细胞和祖细胞的扩增与维持。通过对小鼠胚胎干细胞进行基因靶向操作，我们证明转录因子GATA-2在造血过程中，尤其是在成体造血类型中发挥着关键作用。我们提出，GATA-2调控着控制早期造血细胞生长因子反应性或增殖能力的基因。