[Role of prostaglandins in the regulation of intrapulmonary shunting during lung surgery].

Pulmonary and systemic hemodynamics, gas exchange, intrapulmonary shunting (IS), arterial and mixed venous blood levels of prostaglandin-like substances (PGE + A and PGF2a) have been studied in 63 patients during lung surgery under multicomponent anesthesia with halothane and fentanyl. It has been established that 17% of patients developed intraoperatively arterial hypoxemia associated with IS increase. IS changes resulted from local active release of prostaglandins, mostly E + A group ones, possessing a vasodilating effect in pulmonary vessels.