年龄和链脲佐菌素浓度对禁食大鼠中链脲佐菌素诱导高血糖的影响。
Effect of age and streptozocin concentration on the induction by streptozocin of hyperglycaemia in fasting rats.
作者信息
Wong K K, Wu H M
机构信息
Institute of Pharmacology, National Yang Ming Medical College, Taipei, Taiwan, Republic of China.
出版信息
Biochem Mol Biol Int. 1994 May;33(1):131-6.
The effect of age and streptozocin concentration on the induction by streptozocin of hyperglycaemia in fasting rats is investigated. The data show that there is a dose dependent effect of streptozocin on the hyperglycaemia induced by streptozocin, and 60 mg/kg streptozocin is significantly more effective than 20 or 40 mg/kg streptozocin in inducing hyperglycaemia. Moreover, the hyperglycaemia induced by 60 mg/kg streptozocin is greater in 8 week old rats than in 4 or 6 week old rats, suggesting an influence of age on streptozocin-induced hyperglycaemia.
研究了年龄和链脲佐菌素浓度对禁食大鼠中链脲佐菌素诱导高血糖的影响。数据表明，链脲佐菌素对其诱导的高血糖有剂量依赖性效应，且60mg/kg链脲佐菌素在诱导高血糖方面比20或40mg/kg链脲佐菌素显著更有效。此外，60mg/kg链脲佐菌素诱导的高血糖在8周龄大鼠中比在4或6周龄大鼠中更高，这表明年龄对链脲佐菌素诱导的高血糖有影响。
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