Analysis of polycystic kidney disease with two new microsatellite markers.
作者信息
Bozza A, Stefani S, De Paoli Vitali E, Perini L, del Senno L
机构信息
Dipartimento di Biochimica e Biologia Molecolare, Universitá degli Studi di Ferrara.
出版信息
Boll Soc Ital Biol Sper. 1994 Apr;70(4):129-33.
PMID:8086157
Abstract
Two (CA) microsatellite polymorphisms have been studied in 209 subjects from Northern Italy, members of 27 Polycystic Kidney Disease families. Polymorphic alleles were analyzed by using a labelled PCR. Results obtained show that these markers highly improve the presymptomatic diagnosis of the disease in subjects at risk. In addition, our findings suggest that a region with a high recombination frequency should exist between PKD1 and SM7.
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