Heinsoth V H
MMW Munch Med Wochenschr. 1975 Jul 11;117(28):1199-1204.
In a presentation of the treatment of high blood pressure with saluretics, the course of action especially and the therapeutic aspects of medical prohibition of salt in this indication are discussed in addition to referring to the pathogenetic importance of sodium for hypertension. Two phases of action can be differentiated in the lowering of blood pressure after saluretics. The antihypertensive action in the first (renal) phase is based on the reduction in volume of the extracellular fluid which accompanies the elimination of sodium and water, in the second (extrarenal) phase a lowering of vessel tone and peripheral resistance is responsible.
在关于用利尿剂治疗高血压的报告中,除了提及钠在高血压发病机制中的重要性外,还特别讨论了治疗过程以及针对该适应症医学禁盐的治疗方面。利尿剂降压作用可分为两个阶段。第一阶段(肾脏阶段)的降压作用基于伴随钠和水排出而导致的细胞外液量减少,第二阶段(肾外阶段)则是血管张力和外周阻力降低起作用。