通过模拟对复杂家系进行连锁分析。
Linkage analysis on complex pedigrees by simulation.
作者信息
Thomas A
机构信息
School of Mathematical Sciences, University of Bath, UK.
出版信息
IMA J Math Appl Med Biol. 1994;11(2):79-93. doi: 10.1093/imammb/11.2.79.
PMID:8089591
Abstract
A Markovian scheme for simulating the genotypes of individuals in a pedigree subject to constraints imposed by observed phenotypes is used to estimate the logarithm of a likelihood ratio in linkage analysis. The method is illustrated on a fictitious pedigree by comparison with exactly calculated results.
摘要
一种用于模拟系谱中个体基因型的马尔可夫方案，该系谱受观察到的表型所施加的约束，用于在连锁分析中估计似然比的对数。通过与精确计算结果进行比较，在一个虚拟系谱上展示了该方法。
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