Mukherji S K, Mancuso A A, Kotzur I M, Mendenhall W M, Kubilis P S, Tart R P, Freeman D, Lee W R
Department of Radiology, University of Florida College of Medicine, Shands Teaching Hospital, Gainesville.
Radiology. 1994 Oct;193(1):149-54. doi: 10.1148/radiology.193.1.8090883.
To evaluate the computed tomographic (CT) appearance of laryngeal tumors treated with radiation therapy and the ability of CT to depict persistent or residual tumor.
Sixty-one patients with primary squamous cell carcinoma of the larynx or hypopharynx were treated with definitive radiation therapy. CT was performed in all patients before and after treatment.
In 32 of 41 patients with cancer controlled at the primary site, CT showed complete resolution of tumor, whereas in 10 of 14 patients in whom radiation therapy failed, there was minimal or no reduction in tumor. In a subpopulation of patients who underwent repeat imaging, 18 of 19 with tumor controlled at the primary site had complete resolution of tumor. Overall, in four of 13 patients with 50%-75% reduction in tumor size or persistent substantial asymmetry at CT, therapy eventually failed at the primary site.
Lesions that are reduced by 50% or less at 4-month follow-up CT are highly suspicious for treatment failure. Repeat CT studies every 4 months is recommended in addition to careful clinical follow-up.
评估接受放射治疗的喉肿瘤的计算机断层扫描（CT）表现以及CT描绘持续性或残留肿瘤的能力。
61例原发性喉或下咽鳞状细胞癌患者接受了根治性放射治疗。所有患者在治疗前后均进行了CT检查。
在41例原发部位癌症得到控制的患者中，32例CT显示肿瘤完全消退，而在14例放射治疗失败的患者中，10例肿瘤缩小不明显或未缩小。在接受重复成像的亚组患者中，19例原发部位肿瘤得到控制的患者中有18例肿瘤完全消退。总体而言，13例CT显示肿瘤大小缩小50%-75%或持续存在明显不对称的患者中，有4例最终原发部位治疗失败。
在4个月随访CT时肿瘤缩小50%或更少的病变高度怀疑治疗失败。除了仔细的临床随访外，建议每4个月重复进行CT检查。
