Kinoshita H, Hasegawa T, Kameyama T, Nabeshima T
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Japan.
Res Commun Chem Pathol Pharmacol. 1994 May;84(2):175-87.
We investigated the effects of vinconate, a novel indolonaphthylidine derivative, on maze performance deficits induced by an electrolytic lesion of the basal forebrain (BF) in rats. Bilateral BF lesions were produced by passing an anodal DC current (2 mA, 20 s). In the BF-lesioned groups, the latency and distance that the rat swam to escape onto the platform during training in Morris's water maze task significantly increased. Vinconate (5 and 10 mg/kg) treatment shortened the increase of escape latency to the platform in the BF-lesioned rats. The electrolytic BF lesion caused marked reductions of the contents of monoamines and their metabolites in the fronto-parietal cortex, hippocampus and striatum, while it slightly decreased choline acetyltransferase activity in the fronto-parietal cortex, but not significantly. Vinconate treatment showed a tendency to reverse the decreases of serotonin in the fronto-parietal cortex and hippocampus and dopamine in the striatum. Moreover, the reductions of their metabolites were also slightly attenuated by vinconate. These data suggest that vinconate has an anti-amnesic effect on the electrolytic BF lesion-induced amnesia by partly ameliorating the dysfunction in monoaminergic neurons.
我们研究了新型吲哚萘啶衍生物长春乙酯对大鼠基底前脑（BF）电解损伤所致迷宫行为缺陷的影响。通过施加阳极直流电（2 mA，20 s）造成双侧BF损伤。在BF损伤组中，大鼠在莫里斯水迷宫任务训练期间游向平台以逃脱的潜伏期和距离显著增加。长春乙酯（5和10 mg/kg）治疗缩短了BF损伤大鼠游向平台的逃避潜伏期增加幅度。电解性BF损伤导致额顶叶皮质、海马和纹状体中单胺及其代谢产物含量显著降低，同时它使额顶叶皮质中的胆碱乙酰转移酶活性略有下降，但不显著。长春乙酯治疗显示出逆转额顶叶皮质和海马中5-羟色胺以及纹状体中多巴胺减少的趋势。此外，长春乙酯也使它们代谢产物的减少略有减轻。这些数据表明，长春乙酯通过部分改善单胺能神经元功能障碍，对电解性BF损伤所致失忆具有抗失忆作用。
