o-Chlorobenzenesulfonamidic derivatives of (aryloxy)propanolamines as beta-blocking/diuretic agents. - Suppr | 超能文献

o-Chlorobenzenesulfonamidic derivatives of (aryloxy)propanolamines as beta-blocking/diuretic agents.

作者信息

Cecchetti V, Fravolini A, Schiaffella F, Tabarrini O, Bruni G, Segre G

机构信息

Istituto di Chimica Farmaceutica e Tecnica Farmaceutica, Università di Perugia, Italy.

出版信息

J Med Chem. 1993 Jan 8;36(1):157-61. doi: 10.1021/jm00053a020.

DOI:10.1021/jm00053a020

Abstract

A series of compounds 1b-f, 2b-f, and 3b-f having an o-chlorobenzenesulfonamidic diuretic moiety variously linked to the nitrogen side chain of the beta-blocking (aryloxy)propanolamine pharmacophore were prepared and tested for their beta 1-adrenoceptor affinity. For all the active compounds, beta-blocking and diuretic activities were investigated in rats; the structure--activity relationships are discussed. Some of the compounds displayed varying levels of both properties and among these, compounds 1c and 2c have been chosen for further development.

摘要

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