对氯苯丙氨酸（PCPA）对小鼠食物摄入量、食物通过时间以及大脑和消化道中褪黑素水平的影响。

The effect of para-chlorophenylalanine (PCPA) on food consumption, food transit time and melatonin levels in the brain and the digestive tract of mice.

Bubenik G A, Pang S F

Department of Zoology, University of Guelph, Ontario, Canada.

Comp Biochem Physiol Comp Physiol. 1993 Feb;104(2):377-80. doi: 10.1016/0300-9629(93)90333-y.

Abstract

Food consumption (FC), food transit time (FTT) and melatonin levels in the brain and the digestive tract were determined in control and PCPA-treated mice. 2. FC first increased and then rapidly declined; later returned to its original level. 3. FTT was 22% faster in PCPA treated mice on day 1 but then reached the control levels at day 18. 4. Melatonin levels were higher in PCPA treated mice in the brain, and in all GIT tissues, except the stomach. 5. The described data are consistent with some actions observed after serotonin administration. This paradoxical effect of PCPA is explained by a compensatory feedback mechanism.

摘要

在对照组和经对氯苯丙氨酸（PCPA）处理的小鼠中测定了食物消耗量（FC）、食物通过时间（FTT）以及大脑和消化道中的褪黑素水平。2. 食物消耗量先增加然后迅速下降，随后恢复到初始水平。3. 经PCPA处理的小鼠在第1天的食物通过时间快22%，但在第18天达到对照组水平。4. 经PCPA处理的小鼠大脑以及除胃以外的所有胃肠道组织中的褪黑素水平较高。5. 所述数据与血清素给药后观察到的一些作用一致。PCPA的这种矛盾效应通过代偿性反馈机制来解释。