载脂蛋白A1基因5'侧翼区域遗传标记的特征分析
Characterization of genetic markers in the 5'flanking region of the apo A1 gene.
作者信息
Shoulders C C, Narcisi T M, Jarmuz A, Brett D J, Bayliss J D, Scott J
机构信息
Division of Molecular Medicine, Royal Postgraduate Medical School, London, UK.
出版信息
Hum Genet. 1993 Mar;91(2):197-8. doi: 10.1007/BF00222727.
PMID:8096496
Abstract
Genetic variation of apo A1/C3/A4 is associated with hyperlipidaemia and coronary heart disease. We report the polymerase chain reaction (PCR) conditions for determining three polymorphic sites in the 5'flanking region of apoA1 using DNA prepared from small aliquots of whole blood. These polymorphisms identify six haplotypes that will be of value in genetic studies.
摘要
载脂蛋白A1/C3/A4的基因变异与高脂血症和冠心病相关。我们报告了使用从小份全血制备的DNA来确定载脂蛋白A1 5'侧翼区域三个多态性位点的聚合酶链反应（PCR）条件。这些多态性确定了六种单倍型，它们在基因研究中将具有重要价值。
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