Cherñavsky A C, Chervin A, Vitale M, Basso A, Burdman J A
Instituto de Neurociencias, Sanatorio Güemes, Buenos Aires, Argentina.
Neurol Res. 1993 Feb;15(1):2-6. doi: 10.1080/01616412.1993.11740099.
Searching for differences in gene expression between different types of human pituitary adenomas, we evaluated the concentration of mRNA from hormonal genes (prolactin and growth hormone) and oncogenes (c-myc and c-fos) in 12 growth hormone-secreting 7 prolactin-secreting and 11 nonsecreting adenomas. We found a positive correlation between clinical diagnoses and hormonal gene expression in all the cases. Our reports indicate the presence of c-myc and c-fos mRNA in all the adenomas evaluated. The concentration of c-myc mRNA was higher in somatotrophic adenomas than in prolactinomas and nonsecreting adenomas whereas c-fos mRNA concentration was similar in the different types of tumours analysed. Oncogenes products, in turn, might stimulate DNA synthesis and cell proliferation and eventually lead to the formation of pituitary adenomas. This is a working hypothesis.
为了寻找不同类型人类垂体腺瘤之间的基因表达差异，我们评估了12例生长激素分泌型、7例催乳素分泌型和11例无分泌功能的腺瘤中激素基因（催乳素和生长激素）和癌基因（c-myc和c-fos）的mRNA浓度。我们发现在所有病例中临床诊断与激素基因表达之间存在正相关。我们的报告表明在所评估的所有腺瘤中均存在c-myc和c-fos mRNA。生长激素腺瘤中c-myc mRNA的浓度高于催乳素瘤和无分泌功能的腺瘤，而在所分析的不同类型肿瘤中c-fos mRNA浓度相似。癌基因产物进而可能刺激DNA合成和细胞增殖，并最终导致垂体腺瘤的形成。这是一个可行的假说。
