Preiss D U, Greilich U
Virchows Arch A Pathol Anat Histol. 1975 Sep 18;367(4):255-62. doi: 10.1007/BF01239333.
The development of tension and the ultrastructure of cardiac papillary muscle of normal guinea pigs were compared to guinea pigs receiving lethal doses of diphtheria toxin. The maximal isometric force of the papillary muscles at various levels of resting tension indicated no significant difference between the control and the diphtheritic animals. Neither did the sarcomere lengths of papillary muscles, fixed at various levels of tension, show any significant difference between these two groups. Electronmicroscopy in diphtheritic animals showed intact myofilaments but marked dilatation of the T and L system as well as pathologic fat deposits adjacent to the subsarcolemma and the T system. The results, therefore, suggest that diphtheria toxin acts on the T and L system, but does not affect structure and function of the myofilaments in the acute stage of diphtheria intoxication.
将正常豚鼠与接受致死剂量白喉毒素的豚鼠的心脏乳头肌张力发展和超微结构进行了比较。在不同静息张力水平下，乳头肌的最大等长力表明对照组和患白喉动物之间无显著差异。在不同张力水平固定的乳头肌肌节长度在这两组之间也未显示出任何显著差异。白喉动物的电子显微镜检查显示肌丝完整，但T管和L管系统明显扩张，以及肌膜下和T管系统附近有病理脂肪沉积。因此，结果表明白喉毒素作用于T管和L管系统，但在白喉中毒急性期不影响肌丝的结构和功能。
