α干扰素治疗可减少重度特应性皮炎患者血液中的嗜酸性粒细胞数量。

Interferon-alpha treatment decreases the number of blood eosinophils in patients with severe atopic dermatitis.

作者信息

Paukkonen K, Fräki J, Horsmanheimo M

机构信息

Department of Dermatology, Kuopio University Hospital, Finland.

出版信息

Acta Derm Venereol. 1993 Apr;73(2):141-2. doi: 10.2340/0001555573141142.

DOI:10.2340/0001555573141142

PMID:8103263

Abstract

Eight patients with severe atopic dermatitis were treated with interferon-alpha (IFN-alpha 2b), given by subcutaneous injection, three times a week. The maximum doses varied from 3 to 9 x 10(6) U and the period of treatment from 6 to 14 weeks. The therapy was well tolerated. No changes were observed in eczema or IgE levels, although IFN-alpha 2b treatment significantly decreased blood eosinophils.

摘要

八名重度特应性皮炎患者接受了皮下注射α-干扰素（IFN-α 2b）治疗，每周三次。最大剂量从3至9×10⁶单位不等，治疗周期为6至14周。该疗法耐受性良好。尽管IFN-α 2b治疗使血液嗜酸性粒细胞显著减少，但湿疹或IgE水平未见变化。