Kühböck J, Radaszkiewicz T, Walek H
Med Klin. 1975 Oct 3;70(40):1602-7.
The clinical and pathological findings of peliosis hepatis are reported, complicating a long-term treatment with an anabolic steroid in a 19 year old male patient suffering from chronic aplastic anemia. Following a 15 months course of oxymetholone (Anapolon) a cholestatic jaundice developed without regression despite discontinuing the drug. 4 months later the patient expired as a consequence of his hematologic disease. At autopsy the liver showed a parenchymal type of peliosis hepatis with multiple blood filled cavities and focal liver cell necroses. The pathogenesis of this rare condition is discussed by means of literature demonstrating the hepatotoxic effect of C17-alkylated androgens.
本文报告了肝紫癜病的临床和病理表现，该病例为一名19岁患有慢性再生障碍性贫血的男性患者，在接受合成代谢类固醇长期治疗后出现了并发症。在服用氧甲氢龙（大力补）15个月后，出现了胆汁淤积性黄疸，尽管停药但仍未消退。4个月后，患者因血液系统疾病死亡。尸检发现肝脏呈现实质性肝紫癜病，有多个充满血液的腔隙和局灶性肝细胞坏死。通过文献讨论了这种罕见病症的发病机制，文献表明C17 - 烷基化雄激素具有肝毒性作用。
