鉴定参与N-乙酰-D-甘露糖胺生物合成的一个基因座，N-乙酰-D-甘露糖胺是B群脑膜炎奈瑟菌（α2→8）连接的多聚唾液酸荚膜的前体。
Identification of a genetic locus involved in the biosynthesis of N-acetyl-D-mannosamine, a precursor of the (alpha 2-->8)-linked polysialic acid capsule of serogroup B Neisseria meningitidis.
作者信息
Swartley J S, Stephens D S
机构信息
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303.
出版信息
J Bacteriol. 1994 Mar;176(5):1530-4. doi: 10.1128/jb.176.5.1530-1534.1994.
Abstract
We characterized the genetic defect of a capsule-deficient serogroup B meningococcal strain created by Tn916 mutagenesis. The transposon insertion interrupts a capsule biosynthesis gene, synX, which is involved in the production of N-acetyl-D-mannosamine, a precursor of the (alpha 2-->8)-linked polysialic acid capsule of serogroup B meningococci.
摘要
我们对通过Tn916诱变产生的B群脑膜炎球菌荚膜缺陷菌株的基因缺陷进行了表征。转座子插入中断了一个荚膜生物合成基因synX，该基因参与N-乙酰-D-甘露糖胺的产生，N-乙酰-D-甘露糖胺是B群脑膜炎球菌（α2→8）连接的多聚唾液酸荚膜的前体。
Zotero 插件