I期和II期输卵管癌与上皮性卵巢癌的管理及预后比较分析。
A comparative analysis of management and prognosis in stage I and II fallopian tube carcinoma and epithelial ovarian cancer.
作者信息
Rosen A C, Sevelda P, Klein M, Graf A H, Lahousen M, Reiner A, Auerbach L, Vavra N, Rosen H R
机构信息
Department of Obstetrics and Gynecology, SMZ-Ost, Vienna, Austria.
出版信息
Br J Cancer. 1994 Mar;69(3):577-9. doi: 10.1038/bjc.1994.105.
Staging and surgical as well as post-operative treatment of primary Fallopian tube carcinoma (FTC) followed the lines established for primary ovarian cancer (OC). In a nationwide retrospective analysis we were able to find a distinct difference between these two tumours. A total of 262 patients, 68 with FTC and 194 with OC, in stage I and II were included into this study. A univariate as well as a multivariate analysis for survival was performed, including factors such as age, histological type, grading and surgical and adjuvant treatment. A significantly poorer outcome (P = 0.0002) for FTC patients with a 5-year survival of 50.8% compared with 77.5% for OC patients was observed. This finding was persistent and independent of any investigated factor, in univariate as well as multivariate analyses. Therefore, we feel that a more aggressive therapeutic approach to the treatment of FTC even in early stages can be recommended. On the other hand, the retrospective character of our study has to be taken into account.
原发性输卵管癌（FTC）的分期、手术及术后治疗遵循原发性卵巢癌（OC）所确立的原则。在一项全国性回顾性分析中，我们发现这两种肿瘤之间存在明显差异。本研究纳入了总共262例处于Ⅰ期和Ⅱ期的患者，其中68例为FTC患者，194例为OC患者。对生存情况进行了单因素和多因素分析，包括年龄、组织学类型、分级以及手术和辅助治疗等因素。观察到FTC患者的预后明显较差（P = 0.0002），其5年生存率为50.8%，而OC患者为77.5%。在单因素和多因素分析中，这一发现都是持续存在的，且与任何研究因素无关。因此，我们认为即使在早期阶段，也可以推荐对FTC采取更积极的治疗方法。另一方面，必须考虑到我们研究的回顾性特点。
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