Maeda K, Kato Y, Yamaguchi N, Chihara K, Ohgo S
Acta Endocrinol (Copenh). 1976 Jan;81(1):1-8. doi: 10.1530/acta.0.0810001.
The effect of thyrotrophin-releasing hormone (TRH) or luteinizing hormone-releasing hormone (LH-RH) on plasma levels of growth hormone (GH), prolactin (PRL), thyrotrophin (TSH), and luteinizing hormone (LHY, were studied in patients with anorexia nervosa. The basal plasma GH levels were elevated in 6 of 11 patients studied. Intravenous injection of synthetic TRH T500 mug) significantly raised the plasma GH levels in 9 of 11 patients. The peak values of plasma GH after TRH ranged from 6.0 to 31.5 ng/ml. Plasma GH concentrations also increased following the administration of synthetic LH-RH (100 mug) 1 of 7 patients. The intravenous injection of saline solution caused no significant change in plasma GH in these patients. The plasma LH responses to LH-RH were significantly blunted in all patients, whereas the plasma PRL and TSH responses to TRH were almost normal in the patients examined. These results suggest that the hypothalamo-pituitary function regulating GH and LH secretion is altered in patients with anorexia nervosa.
对神经性厌食症患者研究了促甲状腺激素释放激素（TRH）或促黄体生成素释放激素（LH-RH）对血浆生长激素（GH）、催乳素（PRL）、促甲状腺激素（TSH）和促黄体生成素（LHY）水平的影响。在11例研究患者中，有6例基础血浆GH水平升高。静脉注射合成TRH（500微克）使11例患者中的9例血浆GH水平显著升高。TRH注射后血浆GH的峰值在6.0至31.5纳克/毫升之间。给予合成LH-RH（100微克）后，7例患者中有1例血浆GH浓度也升高。静脉注射生理盐水对这些患者的血浆GH无显著影响。所有患者对LH-RH的血浆LH反应均明显迟钝，而在接受检查的患者中，血浆PRL和TSH对TRH的反应几乎正常。这些结果表明，神经性厌食症患者调节GH和LH分泌的下丘脑-垂体功能发生了改变。
