自发性高血压大鼠和WKY大鼠主动脉中的磷酸肌醇代谢与衰老：内皮素-1和去甲肾上腺素的作用
Phosphoinositide metabolism and aging in aorta from SHR and WKY rats: effects of endothelin-1 and noradrenaline.
作者信息
Pasanisi F, Hamilton C A, Wadsworth R, Pryce C, Nixon G, Reid J L
机构信息
Istituto di Medicine Interna e Malattie Dismetaboliche, II Facolta di Medicina, Napoli, Italy.
出版信息
Clin Exp Hypertens. 1994 Jan;16(1):119-33. doi: 10.3109/10641969409068589.
Inositol phosphate formation in aortic rings from SHR and WKY rats of different ages (6, 14, and 40 weeks) was examined. Both basal and agonist (noradrenaline and endothelin-1) stimulated levels of inositol phosphates were studied. No differences in basal levels of inositol phosphate formation were observed between SHR and WKY nor were differences in agonist stimulated levels found in 6 week old animals. However, at 14 and 40 weeks both noradrenaline and endothelin-1 stimulated levels were reduced in SHR compared to WKY. Both endothelin and noradrenaline stimulated inositol phosphate formation decreased with age in SHR. In WKY there was a decrease in endothelin but not noradrenaline stimulated levels with age. Age related decreases were consistently greater in SHR than WKY. Thus, both age and rat strain modulated agonist stimulated inositol phosphate formation.
研究了不同年龄（6周、14周和40周）的自发性高血压大鼠（SHR）和Wistar-Kyoto大鼠（WKY）主动脉环中肌醇磷酸的形成。研究了基础水平和激动剂（去甲肾上腺素和内皮素-1）刺激后的肌醇磷酸水平。在SHR和WKY之间未观察到基础水平的肌醇磷酸形成差异，在6周龄动物中也未发现激动剂刺激水平的差异。然而，在14周和40周时，与WKY相比，SHR中去甲肾上腺素和内皮素-1刺激的水平均降低。在SHR中，内皮素和去甲肾上腺素刺激的肌醇磷酸形成均随年龄增长而降低。在WKY中，内皮素刺激的水平随年龄增长而降低，但去甲肾上腺素刺激的水平未降低。SHR中与年龄相关的降低始终比WKY更大。因此，年龄和大鼠品系均调节激动剂刺激的肌醇磷酸形成。
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