Nε-甲基组氨酸-促甲状腺素释放激素的质子核磁共振研究。促甲状腺素释放激素（促甲状腺激素释放因子）的一种活性增强类似物。

Proton nuclear magnetic resonance studies of Nepsilon-Me-His2-thyroliberin. An hyperactive analogue of thyroliberin (thyrotropin-releasing factor).

作者信息

Bellocq A M, Dubien M

出版信息

Biochim Biophys Acta. 1976 Jan 20;420(1):1-7. doi: 10.1016/0005-2795(76)90339-1.

Abstract

The 270 MHz Proton magnetic resonance spectra of N-epsilon-Me-His2-thyroliberin in solution in deuterium oxide and deuterated dimethylsulfoxide have been analyzed. All the spectral features (chemical shifts, coupling constants, temperature dependence of NH peptide resonances) clearly show that no significant conformational difference exists between thyroliberin and its analogue. Upon changing solvent from Me2SO-2H6 to 2H2O, both molecules undergo a conformational change which affects the carboxamide group and the backbone of the second residue.

摘要

对N-ε-甲基组氨酸2-促甲状腺素释放激素在氧化氘和氘代二甲亚砜溶液中的270兆赫质子磁共振谱进行了分析。所有光谱特征（化学位移、耦合常数、NH肽共振的温度依赖性）清楚地表明，促甲状腺素释放激素与其类似物之间不存在显著的构象差异。当溶剂从Me2SO-2H6变为2H2O时，两个分子都会发生构象变化，这会影响羧酰胺基团和第二个残基的主链。