Fischereder M, Trick W, Nath K A
Department of Medicine, University of Minnesota, Minneapolis.
Semin Nephrol. 1994 Jan;14(1):41-52.
The current management of acute renal failure rests largely on the avoidance of ischemic and nephrotoxic insults, attention to fluid and electrolyte balance, and the use of dialytic procedures when necessary. The efficacy of several strategies in experimental renal disease, reviewed in this article, raises the possibility that available to the clinician in the not-too-distant future would be analogous interventions that interrupt pathways of tissue injury and/or summon processes that attenuate the damaging effect of a given insult. The implementation of such therapeutic modalities would expand the management of acute renal failure from its current conservative approach to one encompassing therapeutic interventions that potentially prevent the occurrence of acute renal failure. Moreover, the remarkable and ever-increasing understanding of acute renal failure, in all its deranged cell biology and complex pathogenesis, offers the promise of discerning still better and more effective therapeutic interventions.
目前急性肾衰竭的治疗很大程度上依赖于避免缺血性和肾毒性损伤、关注体液和电解质平衡以及在必要时采用透析程序。本文所综述的几种策略在实验性肾脏疾病中的疗效，增加了一种可能性，即在不久的将来临床医生可用的类似干预措施，能够中断组织损伤途径和/或激发减轻特定损伤破坏作用的过程。实施此类治疗方式将把急性肾衰竭的治疗从当前的保守方法扩展到一种包含潜在预防急性肾衰竭发生的治疗干预措施的方法。此外，对急性肾衰竭在其所有紊乱的细胞生物学和复杂发病机制方面的显著且不断增加的认识，为识别更好、更有效的治疗干预措施带来了希望。
