Goldberg S T, Kelleher R T
J Exp Anal Behav. 1976 Jan;25(1):93-104. doi: 10.1901/jeab.1976.25-93.
Rates and patterns of key-press responding maintained under schedules in which responding resulted in intravenous injections of cocaine were studied in squirrel monkeys and rhesus monkeys. Each injection was followed by a 60- or 100-sec timeout period. Schedule-controlled behavior was obtained at appropriate cocaine doses in each species. Under FR 10 or FR 30 schedules, performance was characterized by high rates of responding (usually more than one response per second) in each ratio. Under FI 5-min schedules, performance was characterized by an initial pause, followed by acceleration of responding to a final rate that was maintained until the end of the interval. Under multiple fixed-ratio fixed-interval schedules, rates and patterns of responding appropriate to each schedule component were maintained. Responding seldom occurred during timeout periods under any schedule studied. At doses of cocaine above or below those that maintained characteristic schedule-controlled behavior, rates of responding were relatively low and patterns of responding were irregular. Characteristic fixed-interval responding was maintained over a wider range of cocaine doses than characteristic fixed-ratio responding. Complex patterns of responding controlled by discriminative stimuli under fixed-ratio or fixed-interval schedules can be maintained by cocaine injections in squirrel monkeys and rhesus monkeys.
在松鼠猴和恒河猴中，研究了在按键反应导致静脉注射可卡因的程序下维持的按键反应速率和模式。每次注射后有60秒或100秒的超时时间。在每个物种中，在适当的可卡因剂量下获得了程序控制的行为。在FR 10或FR 30程序下，每个比率的表现特征是反应速率高（通常每秒超过一次反应）。在FI 5分钟程序下，表现特征是开始时有一个停顿，随后反应加速到一个最终速率，并一直维持到间隔结束。在多个固定比率-固定间隔程序下，维持了适合每个程序成分的反应速率和模式。在所研究的任何程序下，超时期间很少发生反应。在维持特征性程序控制行为的可卡因剂量之上或之下，反应速率相对较低，反应模式不规则。与特征性固定比率反应相比，特征性固定间隔反应在更宽的可卡因剂量范围内得以维持。在固定比率或固定间隔程序下，由辨别性刺激控制的复杂反应模式可以通过松鼠猴和恒河猴注射可卡因来维持。
