弥漫性大细胞非霍奇金淋巴瘤中BCL6基因的重排

Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma.

作者信息

Lo Coco F, Ye B H, Lista F, Corradini P, Offit K, Knowles D M, Chaganti R S, Dalla-Favera R

机构信息

Department of Pathology, College of Physicians & Surgeons, Columbia University, New York, NY 10032.

出版信息

Blood. 1994 Apr 1;83(7):1757-9.

PMID:8142643

Abstract

The pathogenesis of non-Hodgkin's lymphoma (NHL) with a large cell component (DLLC, including diffuse large cell, DLCL; diffuse mixed cell, MX-D; and immunoblastic, IMB) is unknown. A novel candidate proto-oncogene, BCL6, that is involved in chromosome band 3q27 aberrations in NHL has been recently identified. We have investigated the incidence and disease-specificity of BCL6 rearrangements in a large panel of lymphoid tumors, including acute and chronic lymphoid leukemias (96 cases), various NHL types (125 cases), and multiple myelomas (23 cases). BCL6 rearrangements were found in 16/45 (35.5%) DLLC, more frequently in DLCL (15/33, 45%) than in MX-D (1/10, 10%), in 2/31 (6.4%) follicular NHL, and in no other tumor types. BCL6 rearrangements represent the first genetic lesion specifically and recurrently associated with DLLC and should prove useful for understanding the pathogenesis as well as for the clinical monitoring of these tumors.

摘要

伴有大细胞成分的非霍奇金淋巴瘤（NHL，包括弥漫性大细胞淋巴瘤，DLCL；弥漫性混合细胞淋巴瘤，MX-D；以及免疫母细胞淋巴瘤，IMB）的发病机制尚不清楚。最近发现了一种新的候选原癌基因BCL6，它与NHL中的3q27染色体带畸变有关。我们研究了一大组淋巴肿瘤中BCL6重排的发生率和疾病特异性，这些肿瘤包括急性和慢性淋巴细胞白血病（96例）、各种类型的NHL（125例）以及多发性骨髓瘤（23例）。在16/45（35.5%）的大细胞淋巴瘤中发现了BCL6重排，其中弥漫性大细胞淋巴瘤（15/33，45%）比弥漫性混合细胞淋巴瘤（1/10，10%）更常见，在2/31（6.4%）的滤泡性NHL中发现了BCL6重排，在其他肿瘤类型中未发现。BCL6重排是首次发现的与大细胞淋巴瘤特异性且反复相关的基因病变，对理解这些肿瘤的发病机制以及临床监测应具有重要意义。