[肾钙结石形成患者对急性酸负荷的钙尿反应过度]

[Exaggerated calciuric response to an acute acid load in patients forming renal calcium stones].

作者信息

Normand M, Cayotte J L, Houillier P, Peuchant A, Paillard M

机构信息

Service de Néphrologie, Clinique Saint Martin, Pessac.

出版信息

Nephrologie. 1993;14(6):283-5.

PMID:8145886

Abstract

Calciuric response to an acute acid load was studied in 13 recurrent calcium stone formers and in 9 control subjects. The evolution of calcium and citrate urinary excretion related to creatinine, of plasma acid base status, of urinary pH, of acid excretion was analysed before and after NH4Cl administration (2 mmol/Kg). Fasting calciuria (expressed as Ca/Cr) was identical in the 2 groups, however the urinary calcium excretion after the acid load was greater in the stone formers group than in the controls (0.378 +/- 0.113 vs 0.253 +/- 0.108 mg/mg). The increase in acid excretion and the decrease in urinary citrate excretion were identical in the 2 groups.

摘要

对13名复发性钙结石形成者和9名对照受试者进行了急性酸负荷后的钙尿反应研究。在给予氯化铵（2 mmol/kg）之前和之后，分析了与肌酐相关的尿钙和柠檬酸盐排泄、血浆酸碱状态、尿pH值、酸排泄的变化情况。两组的空腹尿钙（以Ca/Cr表示）相同，然而，结石形成者组酸负荷后的尿钙排泄量高于对照组（0.378±0.113对0.253±0.108 mg/mg）。两组的酸排泄增加和尿柠檬酸盐排泄减少情况相同。