某些有机锡和铅的卤代及混合卤代-拟卤阴离子配合物的合成与生物学研究

Synthesis and biological studies on some organo-tin and lead halo and mixed halo-pseudohalo anionic complexes.

作者信息

Raj P, Husain I, Singhal K

机构信息

Department of Chemistry, Lucknow University, India.

出版信息

Arzneimittelforschung. 1994 Feb;44(2):178-81.

PMID:8147952

Abstract

Some new anionic complexes of organo-tin(IV) and lead (IV) isolated in combination of tetraorgano-ammonium phosphonium and stibonium cation(s). L[R4-nMXnY] and L2[R2MX2Y2], where R = C2H5, C4H9 or C6H5; M = Sn or Pb; X = Y = Cl = Br, I, N3, NCS; n = 1, 2 and L = R4M1 (M1 = N, P, Sb), whose structures were confirmed by correct elemental analyses, molar conductance values, van't Hoff factor and IR spectral studies, were synthesized and evaluated for anti-convulsant activity in vivo and antiviral and antibacterial activity in vitro. A few of them exhibited promising activity. In addition, the toxicity (ALD50) and effects on the central nervous system of these complexes have been studied in mice.

摘要

一些新的有机锡（IV）和铅（IV）的阴离子配合物，它们是与四有机铵鏻和锑阳离子结合分离得到的。L[R4-nMXnY]和L2[R2MX2Y2]，其中R = C2H5、C4H9或C6H5；M = Sn或Pb；X = Y = Cl、Br、I、N3、NCS；n = 1、2，L = R4M1（M1 = N、P、Sb），通过正确的元素分析、摩尔电导率值、范特霍夫因子和红外光谱研究确定了其结构，并对其进行了体内抗惊厥活性以及体外抗病毒和抗菌活性的评估。其中一些表现出有前景的活性。此外，还研究了这些配合物在小鼠体内的毒性（半数致死剂量）和对中枢神经系统的影响。