4-乙氧基苯丙胺：对大鼠颅内自我刺激以及大脑中3H-多巴胺和3H-5-羟色胺体外摄取与释放的影响。
4-Ethoxyamphetamine: effects on intracranial self-stimulation and in vitro uptake and release of 3H-dopamine and 3H-serotonin in the brains of rats.
作者信息
Hegadoren K M, Greenshaw A J, Baker G B, Martin-Iverson M T, Lodge B, Soin S
机构信息
Department of Psychiatry, University of Alberta, Edmonton Canada.
出版信息
J Psychiatry Neurosci. 1994 Jan;19(1):57-62.
Experiments were conducted to compare the effects of 4-ethoxyamphetamine, a novel "designer" amphetamine, with (+)-amphetamine and an earlier "designer" amphetamine, 4-methoxyamphetamine, on rats. (+)-Amphetamine significantly decreased frequency threshold measures in an intracranial self-stimulation (ICSS) procedure using medial forebrain bundle electrodes, while 4-methoxyamphetamine and 4-ethoxyamphetamine increased these ICSS frequency thresholds. 4-Methoxyamphetamine and 4-ethoxyamphetamine had more potent effects on inhibition of uptake and stimulation of spontaneous release of 5-hydroxytryptamine (serotonin) than of dopamine. It is concluded that the neuropsychopharmacological profile of 4-ethoxyamphetamine is unlike that of (+)-amphetamine, but similar to that of 4-methoxyamphetamine, a potent hallucinogen in humans.
进行了实验以比较新型“设计型”苯丙胺4-乙氧基苯丙胺与（+）-苯丙胺以及早期“设计型”苯丙胺4-甲氧基苯丙胺对大鼠的影响。在使用内侧前脑束电极的颅内自我刺激（ICSS）程序中，（+）-苯丙胺显著降低了频率阈值测量值，而4-甲氧基苯丙胺和4-乙氧基苯丙胺则提高了这些ICSS频率阈值。4-甲氧基苯丙胺和4-乙氧基苯丙胺对5-羟色胺（血清素）摄取抑制和自发释放刺激的作用比对多巴胺的作用更强。得出的结论是，4-乙氧基苯丙胺的神经精神药理学特征与（+）-苯丙胺不同，但与4-甲氧基苯丙胺相似，4-甲氧基苯丙胺是一种对人类有强效致幻作用的物质。
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