Deguchi K, Yokota N, Koguchi M, Suzuki Y, Fukayama S, Ishihara R, Oda S, Tanaka S, Nakane Y, Fukumoto T
Section of Studies, Tokyo Clinical Research Center.
Jpn J Antibiot. 1994 Feb;47(2):143-60.
Using multiple drug-resistant clinical isolates isolated since September 1992, minimum inhibitory concentrations (MICs) of cefpirome (CPR) were determined. Several control drugs were also used, and these MIC-determinations were made to determine the antibiotic activity of CPR. The obtained results are summarized as follows: 1. Antibiotic activities of CPR against methicillin-resistant Staphylococcus spp., Enterococcus faecalis, and benzylpenicillin-insensitive or resistant Streptococcus pneumoniae showed that expanded antibacterial spectrum of CPR and its enhanced antibiotic action against Gram-positive bacteria. We suggest that among the existing fourth-generation cephem antibiotics, CPR is "characteristically strong against Gram-positive bacteria". 2. Strong antibiotic activities of CPR were recognized against bacteria of family Enterobacteriaceae that were resistant to the third-generation cephems. The strong antibiotic activities appeared to be due to CPR's stability and decreased affinity for beta-lactamase. 3. Antibacterial spectrum of CPR was expanded against non-glucose fermented Gram-negative bacilli including Pseudomonas aeruginosa. It appears that this expansion of antibacterial spectrum is due to CPR's affinities for a wide range of penicillin-binding proteins as well as its improved permeability into tissues.
使用自1992年9月以来分离出的多重耐药临床分离株，测定了头孢匹罗（CPR）的最低抑菌浓度（MIC）。还使用了几种对照药物，并进行这些MIC测定以确定CPR的抗菌活性。所得结果总结如下：1. CPR对耐甲氧西林葡萄球菌属、粪肠球菌以及对苄青霉素不敏感或耐药的肺炎链球菌的抗菌活性表明，CPR的抗菌谱有所扩大，且其对革兰氏阳性菌的抗菌作用增强。我们认为，在现有的第四代头孢菌素类抗生素中，CPR“对革兰氏阳性菌具有独特的强效作用”。2. 认识到CPR对耐第三代头孢菌素的肠杆菌科细菌具有强效抗菌活性。这种强效抗菌活性似乎归因于CPR的稳定性以及对β-内酰胺酶的亲和力降低。3. CPR对包括铜绿假单胞菌在内的非葡萄糖发酵革兰氏阴性杆菌的抗菌谱有所扩大。这种抗菌谱的扩大似乎归因于CPR对多种青霉素结合蛋白的亲和力以及其改善的组织通透性。
