Cunliffe I A, Longstaff S
Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, U.K.
Acta Ophthalmol (Copenh). 1993 Dec;71(6):739-43. doi: 10.1111/j.1755-3768.1993.tb08593.x.
This study reviews the outcome of 14 eyes considered to be at risk of surgical failure undergoing trabeculectomy with 5-Fluorouracil (5-FU). The antimetabolite was administered intra-operatively by placing a surgical sponge soaked in 5-FU (25 mg/ml) directly on the sclera under the conjunctival flap for 5 minutes. All eyes showed a reduction in intraocular pressure (IOP) at a mean follow-up of 18.5 weeks, and only one eye required topical antiglaucoma medication. Mean IOP reduction at final follow-up was 43.1%. No eyes showed any corneal problems associated with the intra-operative use of 5-FU. These results suggest that the intra-operative use of 5-Fluorouracil is an effective way of improving surgical success in at risk eyes. The early complications appear to be less than those associated with post-operative subconjunctival injections of 5-FU, but the long-term differences are still to be shown.
本研究回顾了14只被认为有手术失败风险的眼睛接受含5-氟尿嘧啶（5-FU）小梁切除术的结果。术中通过将浸泡在5-FU（25毫克/毫升）中的手术海绵直接置于结膜瓣下的巩膜上5分钟来给予这种抗代谢药物。所有眼睛在平均18.5周的随访中眼压（IOP）均有所降低，且只有一只眼睛需要局部抗青光眼药物治疗。末次随访时平均眼压降低43.1%。没有眼睛出现与术中使用5-FU相关的任何角膜问题。这些结果表明，术中使用5-氟尿嘧啶是提高有风险眼睛手术成功率的有效方法。早期并发症似乎比术后结膜下注射5-FU的并发症少，但长期差异仍有待证明。
