Valero A L, Bescos M, Amat P, Malet A
Al.Lergo Centre, Barcelona.
Allergol Immunopathol (Madr). 1993 Nov-Dec;21(6):221-4.
A case is reported of a patient with episodes of bronchospasm requiring hospital admission after handling sodium bisulfite on the job. The patient had a 15-year history of bronchial asthma and concomitant rhinoconjunctivitis and a 6-year history of asthma induced by moderate exercise. His family history included a father with sensitization to mites. Skin tests, measurement of specific IgI, and nasal provocation were positive for domestic dust mites and grass pollen. Skin tests for sodium metasulfite at a concentration of 10 mg/ml were negative. A simple blind oral provocation test of sodium metasulfite (1, 5, 20, and 50 mg) in acid medium was positive at the 50-mg dose, eliciting bronchial and nasal symptoms, and a decrease in CVF, FEV1, and PEF of more than 20% over baseline values. The episode of bronchospasm has not recurred in the workplace since exposure to sodium bisulfite was eliminated. Oral provocation with metasulfite in acid medium is considered a good technique for confirming the diagnosis of these cases.
报告了1例患者，该患者在工作中接触亚硫酸氢钠后出现支气管痉挛发作，需住院治疗。该患者有15年支气管哮喘病史，伴有鼻结膜炎，并有6年中度运动诱发哮喘病史。其家族史包括父亲对螨虫敏感。皮肤试验、特异性IgI测量和鼻激发试验显示对屋尘螨和草花粉呈阳性。浓度为10 mg/ml的偏亚硫酸氢钠皮肤试验为阴性。在酸性介质中对偏亚硫酸氢钠（1、5、20和50 mg）进行的简单盲法口服激发试验在50 mg剂量时呈阳性，引发支气管和鼻部症状，且CVF、FEV1和PEF较基线值下降超过20%。自消除亚硫酸氢钠接触后，工作场所未再发生支气管痉挛发作。在酸性介质中用亚硫酸盐进行口服激发试验被认为是确诊这些病例的良好技术。
