Tillyer M L, Tillyer C R
Department of Haematology, Newham General Hospital, London.
J Clin Pathol. 1994 Mar;47(3):205-8. doi: 10.1136/jcp.47.3.205.
To determine the value of the red cell distribution width (RDW) and erythrocyte zinc protoporphyrin (ZPP) concentration in discriminating between iron deficiency, and beta and alpha thalassaemia in a mixed urban Asian population.
The RDW and ZPP concentrations were measured in 1412 subjects attending for outpatient phlebotomy, with classification into diagnostic groups on the basis of haemoglobin, mean cell haemoglobin, ferritin, HbA2 and haemoglobin electrophoresis.
Non-parametric 95% reference ranges for RDW were 11.7-15.7% and for ZPP 38-104 mumol/mol haem. Both RDW and zinc protoporphyrin rose with increasing severity of iron deficiency, but were also raised in significant numbers of subjects with beta and probable alpha thalassaemia.
Measurements of RDW and ZPP do not differentiate between alpha or beta thalassaemia trait and moderate degrees of iron deficiency (hypochromasia without anaemia). ZPP is a more accurate indicator of iron deficiency than RDW and concentrations above 150 mumol/mol haem strongly suggest iron deficiency, usually with anaemia, rather than thalassaemia.
确定在亚洲城市混合人群中，红细胞分布宽度（RDW）和红细胞锌原卟啉（ZPP）浓度在鉴别缺铁性贫血、β地中海贫血和α地中海贫血方面的价值。
对1412名前来门诊进行静脉采血的受试者测量其RDW和ZPP浓度，并根据血红蛋白、平均红细胞血红蛋白、铁蛋白、HbA2和血红蛋白电泳结果将其分类为不同诊断组。
RDW的非参数95%参考范围为11.7 - 15.7%，ZPP为38 - 104 μmol/mol血红素。RDW和锌原卟啉均随缺铁严重程度的增加而升高，但在大量β地中海贫血和可能的α地中海贫血患者中也升高。
RDW和ZPP的测量不能区分α或β地中海贫血特征与中度缺铁（无贫血的低色素血症）。ZPP是比RDW更准确的缺铁指标，浓度高于150 μmol/mol血红素强烈提示缺铁，通常伴有贫血，而非地中海贫血。
