Mandak M, Kerbl U, Kleinert R, Höfler G, Zeichen R, Denk H
Interne Abteilung, Landeskrankenhaus Hörgas, Gratwein.
Wien Klin Wochenschr. 1994;106(4):111-4.
A woman aged 63 presented with septic fever, followed by hepatocellular jaundice. Viral hepatitis was ruled out by serologic tests, but no definite diagnosis could be made. Due to severe disturbance of the plasmatic coagulatory system and a serum bilirubin level above 4 mg/dl, a liver biopsy was not performed. The patient had a persistent septicemia refractory to Imipenem. In spite of intensive care measures, the patient died of disseminated intravascular coagulation and multiorgan failure caused by septic shock. The correct diagnosis of miliary tuberculosis was made only post mortem by histopathological examination of liver specimens and confirmed by detection of Mycobacterium tuberculosis DNA in the patient's liver by polymerase chain reaction.
一名63岁女性出现败血症热,随后出现肝细胞性黄疸。血清学检查排除了病毒性肝炎,但无法做出明确诊断。由于血浆凝血系统严重紊乱且血清胆红素水平高于4mg/dl,未进行肝活检。患者患有对亚胺培南耐药的持续性败血症。尽管采取了重症监护措施,患者仍死于败血症休克引起的弥散性血管内凝血和多器官功能衰竭。仅在尸检时通过肝脏标本的组织病理学检查才做出粟粒性结核病的正确诊断,并通过聚合酶链反应在患者肝脏中检测到结核分枝杆菌DNA得以证实。