Melchers F, Karasuyama H, Haasner D, Bauer S, Kudo A, Sakaguchi N, Jameson B, Rolink A
Basel Institute for Immunology, Switzerland.
Immunol Today. 1993 Feb;14(2):60-8. doi: 10.1016/0167-5699(93)90060-X.
The proteins encoded by the VpreB and lambda 5 genes associate with each other to form a light (L) chain-like structure, the surrogate L chain. It can form Ig-like complexes with three partners-the classical heavy (H) chain, the DHJHC mu-protein, or the newly discovered p55 chain; these are expressed on the surface of pre-B cells at different stages of development. Here, Fritz Melchers and colleagues review the structures of the VpreB and lambda 5 genes in mouse and their relatives in humans, describe their pattern of expression, and speculate on their possible evolution and functions.
由VpreB和lambda 5基因编码的蛋白质相互结合，形成一种类似轻（L）链的结构，即替代L链。它可以与三种伴侣形成Ig样复合物——经典重（H）链、DHJHCμ蛋白或新发现的p55链；这些在不同发育阶段的前B细胞表面表达。在此，弗里茨·梅尔切斯及其同事综述了小鼠中VpreB和lambda 5基因及其人类同源基因的结构，描述了它们的表达模式，并推测了它们可能的进化和功能。
