Eroglu G E, Scopelitis E
Department of Medicine, Louisiana State University Medical Center, New Orleans.
Am J Reprod Immunol. 1994 Jan;31(1):1-6. doi: 10.1111/j.1600-0897.1994.tb00840.x.
To determine the presence of absence of subclinical autoimmunity in healthy women with first trimester recurrent spontaneous abortion (RSA), the sera of 72 healthy women with a history of three or more consecutive abortions were analyzed for the presence of antibodies to phospholipid and nuclear antigens.
Lupus anticoagulant was determined, as were antibodies to cardiolipin. An indirect immunofluorescent antinuclear test was performed and specific antinuclear antibodies to double-stranded DNA, ribonucleoprotein, Smith antigen, and Sjogren's syndrome A and B antigens were tested.
Nine women (13.2%) had low levels of antinuclear antibodies, none of which were specific. Four women (5.6%) had moderate to high levels of aCL antibodies.
We conclude that the prevalence of aCLs and antinuclear antibodies in healthy women with first trimester RSA is low. Subclinical autoimmunity is not a common cause of first trimester RSA.
为了确定孕早期复发性自然流产（RSA）的健康女性是否存在亚临床自身免疫，对72名有连续三次或更多次流产史的健康女性血清进行分析，以检测抗磷脂和核抗原抗体的存在情况。
检测狼疮抗凝物以及抗心磷脂抗体。进行间接免疫荧光抗核试验，并检测针对双链DNA、核糖核蛋白、史密斯抗原以及干燥综合征A和B抗原的特异性抗核抗体。
9名女性（13.2%）抗核抗体水平较低，均无特异性。4名女性（5.6%）抗心磷脂抗体水平为中度至高度。
我们得出结论，孕早期RSA的健康女性中抗心磷脂抗体和抗核抗体的患病率较低。亚临床自身免疫不是孕早期RSA的常见原因。
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