Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1.
作者信息
Araki E, Haag B L, Kahn C R
机构信息
Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215.
出版信息
Biochim Biophys Acta. 1994 Apr 28;1221(3):353-6. doi: 10.1016/0167-4889(94)90261-5.
PMID:8167159
Abstract
The mouse IRS-1 gene has been cloned and its structure determined. Mouse IRS-1 differs from rat by the absence of the potential C-terminal nucleotide binding site. Otherwise, the predicted IRS-1 protein is highly conserved between mouse, rat and humans, especially in the possible phosphorylation sites. The highly conserved nature of IRS-1 suggests the importance of these domains in the function of IRS-1 or its association with other proteins.
摘要
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