MDM2的转录多态性与亚定位
A transcribed polymorphism and sub-localisation of MDM2.
作者信息
Heighway J, Mitchell E L, Jones D, White G R, Santibáñez Koref M F
机构信息
CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie CRC Research Centre, Manchester, UK.
出版信息
Hum Genet. 1994 May;93(5):611-2. doi: 10.1007/BF00202837.
PMID:8168847
Abstract
An NlaIV polymorphism in the 5' untranslated region of the MDM2 gene is described. MDM2 was sublocalised by fluorescence in situ hybridisation with a yeast artificial chromosome probe to 12q14.3-12q15. We demonstrate the use of the polymorphism to assess allelic imbalance in breast tumours.
摘要
描述了MDM2基因5'非翻译区的一种NlaIV多态性。通过使用酵母人工染色体探针进行荧光原位杂交，将MDM2亚定位到12q14.3 - 12q15。我们展示了利用该多态性来评估乳腺肿瘤中的等位基因失衡。
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