Fortney J A, Feldblum P J, Talmage R V, Zhang J, Godwin S E
Family Health International, Research Triangle Park Branch, Durham, NC 27709.
J Reprod Med. 1994 Feb;39(2):105-9.
To examine the relationship between oral contraceptive (OC) use and bone mineral density (BMD), we conducted a cross-sectional study on 352 white, nonsmoking, perimenopausal women aged 40-54 years. We measured bone mineral density of lumbar vertebrae 2-4 with dual photon absorptiometry and mid-radius and distal radius with single photon absorptiometry. After controlling for age, body mass, current physical activity, current calcium intake and history of breastfeeding, our analysis did not find substantial differences in BMD at any site between OC ever users and never users. However, OC ever users had slightly higher lumbar BMD among premenopausal women. No significant association was identified between recency of OC use and BMD. The results of our study suggest that when other factors are accounted for, OC use is not strongly associated with BMD among perimenopausal women, although we cannot exclude a slight beneficial effect.
为了研究口服避孕药（OC）的使用与骨矿物质密度（BMD）之间的关系，我们对352名年龄在40至54岁之间的白人、不吸烟的围绝经期妇女进行了一项横断面研究。我们使用双能光子吸收法测量了第2至4腰椎的骨矿物质密度，并使用单能光子吸收法测量了桡骨中段和远端的骨矿物质密度。在控制了年龄、体重、当前身体活动、当前钙摄入量和母乳喂养史之后，我们的分析未发现曾经使用过OC的女性和从未使用过OC的女性在任何部位的骨矿物质密度存在实质性差异。然而，在绝经前女性中，曾经使用过OC的女性腰椎骨矿物质密度略高。未发现OC使用近期情况与骨矿物质密度之间存在显著关联。我们的研究结果表明，在考虑其他因素时，围绝经期女性使用OC与骨矿物质密度之间没有强烈关联，尽管我们不能排除轻微的有益影响。
