急性心肌梗死合并轻度左心室功能不全患者的心房利钠肽反应减弱。

Atrial natriuretic peptide response is blunted in patients with acute myocardial infarction and mild left ventricular dysfunction.

作者信息

Derchi G, Bellone P, Tommasini G, Biorci M L, Randazzo M, Primarolo P, Vecchio C

机构信息

Cardiology Division, EO Ospedali Galliera, Genova, Italy.

出版信息

Cardiology. 1994;84(2):79-88. doi: 10.1159/000176525.

DOI:10.1159/000176525

PMID:8174145

Abstract

Neurohumoral parameters in 45 asymptomatic patients with acute myocardial infarction were measured. In patients with mild left ventricular dysfunction (ejection fraction < or = 45% and/or left ventricular end-diastolic pressure > or = 15 mm Hg), atrial natriuretic peptide levels differed significantly from those in patients with normal left ventricular function (127 +/- 74 pg/ml vs. 79 +/- 71 pg/ml; p < 0.001). After stimulus an increase in atrial natriuretic peptide levels (79 +/- 71 to 118 +/- 86 pg/ml; p < 0.001) was found only in patients with normal hemodynamic parameters. These data show that in patients with left ventricular dysfunction, the atrial natriuretic system is activated; however, atrial natriuretic peptide response to stimulus is present only in patients with normal hemodynamics.

摘要

对45例无症状急性心肌梗死患者的神经体液参数进行了测量。在轻度左心室功能不全（射血分数≤45%和/或左心室舒张末期压力≥15mmHg）的患者中，心房利钠肽水平与左心室功能正常的患者有显著差异（127±74pg/ml对79±71pg/ml；p<0.001）。刺激后，仅在血流动力学参数正常的患者中发现心房利钠肽水平升高（79±71至118±86pg/ml；p<0.001）。这些数据表明，在左心室功能不全的患者中，心房利钠系统被激活；然而，仅在血流动力学正常的患者中存在心房利钠肽对刺激的反应。