Krissel J, Dick W F, Leyser K H, Gervais H, Brockerhoff P, Schranz D
Clinic of Anaesthesiology, Johannes Gutenberg-University Hospital, Mainz, Germany.
Eur J Anaesthesiol. 1994 Mar;11(2):115-22.
Seventy-five healthy patients were randomly allocated to receive thiopentone, thiopentone/ketamine or ketamine for induction of anaesthesia for elective Caesarean section. Thiopentone resulted in the most pronounced and ketamine in the smallest drop in blood pressure, while the combination induced only moderate haemodynamic changes. Intra-operative awareness occurred in one patient in the thiopentone group, six of the ketamine patients had nightmares, and one patient of the combination group reported pleasant dreams but no awareness. The muscle tone of neonates in the thiopentone group was more reduced than in neonates in the other two groups. Infants delivered after uterine incision-to-delivery intervals exceeding 3 min more often had Apgar scores < 7 than those delivered in less than 3 min.
75名健康患者被随机分配接受硫喷妥钠、硫喷妥钠/氯胺酮或氯胺酮用于择期剖宫产的麻醉诱导。硫喷妥钠导致血压下降最为明显，氯胺酮导致血压下降幅度最小，而联合用药仅引起中度血流动力学变化。硫喷妥钠组有1例患者术中知晓，氯胺酮组有6例患者出现噩梦，联合用药组有1例患者报告做了愉快的梦但无知晓。硫喷妥钠组新生儿的肌张力比其他两组新生儿的肌张力降低更明显。子宫切开至分娩间隔超过3分钟娩出的婴儿比在3分钟内娩出的婴儿更常出现阿氏评分<7分。
