海马体中的乙酰胆碱释放：内侧隔区中胆碱能和γ-氨基丁酸能化合物的作用。

Acetylcholine release in the hippocampus: effects of cholinergic and GABAergic compounds in the medial septal area.

作者信息

Gorman L K, Pang K, Frick K M, Givens B, Olton D S

机构信息

Johns Hopkins University, Department of Psychology, Baltimore, MD 21218.

出版信息

Neurosci Lett. 1994 Jan 31;166(2):199-202. doi: 10.1016/0304-3940(94)90485-5.

DOI:10.1016/0304-3940(94)90485-5

PMID:8177500

Abstract

The medial septal area (MSA) contains cholinergic and GABAergic neurons that send projections to the hippocampus. These neurons have both cholinergic and GABAergic receptors. This study was designed to determine the effects of intraseptal infusions of cholinergic and GABAergic drugs, which alter mnemonic processes, on hippocampal acetylcholine (ACh) release. Hippocampal ACh release was assessed using in vivo microdialysis and HPLC-EC. Oxotremorine and scopolamine produced a dose-dependent decrease in hippocampal ACh release. Muscimol decreased hippocampal ACh release at both high and low doses, although not in a dose-dependent manner. The effects of scopolamine and muscimol are consistent with a role of ACh in mnemonic processing.

摘要

内侧隔区（MSA）包含向海马体发送投射的胆碱能和γ-氨基丁酸能神经元。这些神经元同时具有胆碱能和γ-氨基丁酸能受体。本研究旨在确定改变记忆过程的胆碱能和γ-氨基丁酸能药物的隔内输注对海马体乙酰胆碱（ACh）释放的影响。使用体内微透析和高效液相色谱-电化学检测法评估海马体ACh释放。氧化震颤素和东莨菪碱使海马体ACh释放呈剂量依赖性降低。蝇蕈醇在高剂量和低剂量时均降低海马体ACh释放，尽管不是呈剂量依赖性。东莨菪碱和蝇蕈醇的作用与ACh在记忆加工中的作用一致。