Hochstrasser K, Albrecht G J, Gebhard W, Rasp G, Kastenbauer E
Ludwig-Maximilians-Universität München, Klinikum Grosshadern, HNO-Forschung, Germany.
Eur Arch Otorhinolaryngol. 1994;251(1):30-5. doi: 10.1007/BF00175954.
The mast-cell-specific proteolytic enzymes tryptase and chymase were identified in and isolated from cholesteatoma in a ratio similar to that found in human skin. We assume that this ratio reflects a similar distribution of tryptase-containing and tryptase/chymase-containing mast cells in both these tissues. It seems conceivable that mechanisms able to trigger excessive and/or continuous mast cell degranulation in the middle ear might be causative for the formation of cholesteatoma either directly or via primed chronic inflammatory reactions. By their ability to amplify degranulation of mast cells, mast cell proteinases, in particular chymase, may contribute to the chain of events leading to the formation of cholesteatoma.
在胆脂瘤中鉴定并分离出肥大细胞特异性蛋白水解酶类胰蛋白酶和糜蛋白酶，其比例与人皮肤中的比例相似。我们推测，该比例反映了这两种组织中含类胰蛋白酶的肥大细胞和含类胰蛋白酶/糜蛋白酶的肥大细胞的相似分布。似乎可以想象，能够触发中耳内肥大细胞过度和/或持续脱颗粒的机制可能直接或通过引发慢性炎症反应导致胆脂瘤的形成。肥大细胞蛋白酶，尤其是糜蛋白酶，因其能够放大肥大细胞的脱颗粒作用，可能在导致胆脂瘤形成的一系列事件中发挥作用。
