大鼠胶质瘤快中子照射期间的硼中子俘获同步治疗。
Concomitant boron-neutron capture therapy during fast-neutron irradiation of a rat glioma.
作者信息
Buchholz T A, Rasey J S, Laramore G E, Livesey J C, Chin L, Risler R, Hamlin D K, Spence A M, Griffin T W
机构信息
Department of Radiation Oncology, University of Washington, Seattle.
出版信息
Radiology. 1994 Jun;191(3):863-7. doi: 10.1148/radiology.191.3.8184080.
PURPOSE
Fast-neutron irradiation and boron-neutron capture therapy (BNCT) have been independently investigated as treatments for malignant disease. This study tested the feasibility of enhancing fast-neutron irradiation with concomitant BNCT.
MATERIALS AND METHODS
Seventeen male Fisher rats, each weighing 180-200 g and bearing 36B10 gliomas, were irradiated with graded doses of fast-neutron radiation. Half of the animals received an L-para-boronophenylalanine (BPA) fructose complex prior to treatment. An in vitro colony-forming assay was used to measure surviving fraction.
RESULTS
A significantly lower surviving fraction was noted in the tumors from the BPA group compared with those receiving neutrons alone at the three lower neutron doses (P < .005). With use of a linear quadratic curve fit of cell survival, the dose modifying factor was 1.32 at the 0.10 surviving fraction. Mean tumor boron concentration was 68.4 micrograms/g.
CONCLUSIONS
BNCT enhancement of fast-neutron irradiation is feasible in an in vivo tumor system.
目的
快中子辐照和硼中子俘获疗法（BNCT）已分别作为恶性疾病的治疗方法进行研究。本研究测试了联合BNCT增强快中子辐照的可行性。
材料与方法
17只雄性Fisher大鼠，每只体重180 - 200 g，均患有36B10胶质瘤，接受不同剂量的快中子辐射。一半动物在治疗前接受L - 对硼苯丙氨酸（BPA）果糖复合物。采用体外集落形成试验测量存活分数。
结果
在三个较低中子剂量下，与仅接受中子照射的动物相比，BPA组肿瘤的存活分数显著降低（P < 0.005）。利用细胞存活的线性二次曲线拟合，在存活分数为0.10时剂量修正因子为1.32。肿瘤平均硼浓度为68.4微克/克。
结论
在体内肿瘤系统中，BNCT增强快中子辐照是可行的。
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