在钙和无机磷酸盐诱导的线粒体通透性转变过程中吡啶核苷酸的氧化以及ATP和ADP的消耗。

Oxidation of pyridine nucleotides and depletion of ATP and ADP during calcium- and inorganic phosphate-induced mitochondrial permeability transition.

作者信息

Savage M K, Reed D J

机构信息

Department of Biochemistry and Biophysics, Oregon State University, Corvallis 97331.

出版信息

Biochem Biophys Res Commun. 1994 May 16;200(3):1615-20. doi: 10.1006/bbrc.1994.1636.

DOI:10.1006/bbrc.1994.1636

PMID:8185617

Abstract

We have examined the pyridine and adenine nucleotide status during calcium- and inorganic phosphate-induced permeability transition. Calcium- and inorganic phosphate-induced permeability transition is accompanied by the rapid oxidation of pyridine nucleotides and depletion of ATP and ADP with conversion to AMP. The addition of cyclosporin A, a potent inhibitor of the permeability transition prevented the oxidation of pyridine nucleotides and depletion of ATP and ADP.

摘要

我们研究了钙和无机磷酸盐诱导的通透性转变过程中的吡啶和腺嘌呤核苷酸状态。钙和无机磷酸盐诱导的通透性转变伴随着吡啶核苷酸的快速氧化以及ATP和ADP的消耗，并转化为AMP。添加环孢菌素A（一种有效的通透性转变抑制剂）可防止吡啶核苷酸的氧化以及ATP和ADP的消耗。