Suei Y, Tanimoto K, Taguchi A, Wada T
Department of Oral and Maxillofacial Radiology, Hiroshima University School of Dentistry, Japan.
J Oral Maxillofac Surg. 1994 Jun;52(6):580-3. doi: 10.1016/0278-2391(94)90094-9.
Twenty-four reports describing 39 cases of primary intraosseous carcinoma (PIOC) were reviewed and the clinicopathologic features were summarized. The mean age of the patients at the time of diagnosis was 51.0 years, and the male: female ratio was 2:3. The posterior mandible was the predominant site; in no patient was a lesion observed in the posterior maxilla. Twenty-five of 31 patients (80.6%) showed swelling of the oral mucosa. However, ulcer formation was observed in only 3 of 36 patients. Pain, sensory disturbances, and metastasis to regional lymph nodes were observed in 25 of 34 patients (73.5%), 9 of 15 patients (60%), and 13 of 33 patients (39.4%), respectively. Radiographically, most lesions produced bone resorption with ill-defined margins (51.6%) or with well-defined margins (19.4%). The diagnostic criteria proposed for PIOC are absence of ulcer formation, except when caused by other factors; histologic evidence of squamous cell carcinoma without a cystic component or other odontogenic tumor cells; and absence of another primary tumor on chest radiographs obtained at the time of diagnosis and during a follow-up period of more than 6 months.
回顾了24篇描述39例原发性骨内癌（PIOC）的报告，并总结了其临床病理特征。患者诊断时的平均年龄为51.0岁，男女比例为2:3。下颌骨后部是主要发病部位；上颌骨后部未观察到病变。31例患者中有25例（80.6%）出现口腔黏膜肿胀。然而，36例患者中仅3例出现溃疡形成。34例患者中有25例（73.5%）出现疼痛、感觉障碍，15例患者中有9例（60%）出现区域淋巴结转移，33例患者中有13例（39.4%）出现区域淋巴结转移。影像学上，大多数病变表现为骨质吸收，边界不清（51.6%）或边界清晰（19.4%）。PIOC的诊断标准为：除其他因素引起外，无溃疡形成；组织学证据显示为无囊性成分或其他牙源性肿瘤细胞的鳞状细胞癌；诊断时及随访6个月以上期间胸部X线片未见其他原发性肿瘤。
