日本掌跖脓疱病患者 HLA - A、-B、-C 和 -DR 抗原的基因多态性

Genetic polymorphisms in HLA-A, -B, -C and -DR antigens in Japanese patients with palmoplantar pustulosis.

作者信息

Torii H, Nakagawa H, Ishibashi Y, Tokunaga K, Juji T

机构信息

Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.

出版信息

Dermatology. 1994;188(4):290-2. doi: 10.1159/000247168.

DOI:10.1159/000247168

PMID:8193402

Abstract

Genetic polymorphisms in HLA-A, -B, -C and -DR antigens were investigated in 78 unrelated Japanese patients with palmoplantar pustulosis (PPP) and compared with a total of 472 normal persons. Only HLA-DR9 showed a significantly increased frequency among all HLA antigens investigated (chi 2 = 11.57, p < 0.001). It is suggested that major histocompatibility complex class II antigens including HLA-DR antigen may determine the susceptibility to PPP and PPP may be a distinct disease entity from psoriasis.

摘要

对78例无亲缘关系的日本掌跖脓疱病（PPP）患者的HLA - A、- B、- C和 - DR抗原的基因多态性进行了研究，并与总共472名正常人进行了比较。在所研究的所有HLA抗原中，只有HLA - DR9的频率显著增加（卡方 = 11.57，p < 0.001）。提示包括HLA - DR抗原在内的主要组织相容性复合体II类抗原可能决定对PPP的易感性，并且PPP可能是一种与银屑病不同的疾病实体。