Crabbe J C
Research Service, VA Medical Center, Portland, OR 97201.
Alcohol Clin Exp Res. 1994 Feb;18(1):42-6. doi: 10.1111/j.1530-0277.1994.tb00878.x.
COLD and HOT mice have been selected to be sensitive or resistant, respectively, to the acute hypothermic effect of ethanol. Previous studies have found HOT mice to be relatively resistant to the development of tolerance to this effect, whereas COLD mice readily develop tolerance. By administering several doses of ethanol and recording multiple postdrug temperatures, in the current study we equated the selected lines for area under the curve describing initial hypothermic response over time, a measure reflecting both maximal hypothermia achieved and the duration of total hypothermic response. The dose-response function for COLD mice was much steeper than that for HOT mice, and HOT mice recovered to baseline body temperatures more slowly. Doses were administered daily for 5 days. Both lines developed tolerance to ethanol hypothermia. The magnitude of tolerance developed was greater in COLD than in HOT mice. At higher doses, HOT mice showed a progressively enhanced hypothermic response over days (i.e., sensitization).
“冷反应”小鼠和“热反应”小鼠分别被选作对乙醇急性体温降低效应敏感或耐受的品系。先前的研究发现，“热反应”小鼠对这种效应的耐受性发展相对较慢，而“冷反应”小鼠则很容易产生耐受性。在本研究中，通过给予几剂乙醇并记录给药后的多个体温，我们使选定的品系在描述初始体温降低反应随时间变化的曲线下面积相等，这一指标反映了达到的最大体温降低程度和总体温降低反应的持续时间。“冷反应”小鼠的剂量 - 反应函数比“热反应”小鼠的陡峭得多，并且“热反应”小鼠恢复到基线体温的速度更慢。每天给药，持续5天。两个品系都对乙醇诱导的体温降低产生了耐受性。“冷反应”小鼠产生的耐受性程度比“热反应”小鼠更大。在较高剂量下，“热反应”小鼠在数天内表现出逐渐增强的体温降低反应（即致敏）。
